Sheep Monoclonal Antibodies (SMAs) to Estriol (E3) E3.8A4

PRODUCT DATA SHEET

Product Data Sheet:  Sheep Monoclonal Antibodies (SMAs) to Estriol (E3) 

SMA Covered: E3.8A4 & E3.12G3 

Introduction and  Production Description:  The assay of estriol is of interest in biological samples  such as serum. During pregnancy estriol becomes the  dominant estrogen and serum levels increase from  0.3 ng/mL to above 8.0 ng/mL. Its main use is in the  diagnosis of foetal diseases.  High affinity antibodies are  useful in facilitating immunoassays capable of measuring  such low levels. Assay designs are likely to benefit from  the use of estradiol-6-X (ie E2) reagents or other non estriol conjugates.

Manufacturing Specification

Parameter                                              Specification                                                              Test Method

Buffer and pH                            PBS +0.1% Sodium azide  at 7.2-7.4                                      pH Meter

Antibody Concentration            1-3 mg/mL                                                                                A280 (Ec = 1.4)

Purity and Aggregates              Single Main Peak ≥95%                                                            Size Exclusion HPLC

Immunological Activity              ±20% biological activity of  frozen reference standard              In house ELISA

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